6 Minute Walk Test

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General Information
Background
Author/s or Creator/s
Julaine Florence & the Outcome Measure committee of the SMA ICC
Objectives
The Six-Minute Walk Test (6MWT) is an objective evaluation of functional exercise capacity which measures how far a person can walk in six minutes (ATS 2002). It is a global measure of multiple body systems including cardiopulmonary, vascular and neuromuscular.
Category of Outcome Measure
Functional
 
Disease Type
Unknown
Chronology of Development
The following procedures are based on the ATS guidelines for administering the test with modifications for SMA.
Time Information
Time to Recall
At Assessment
Recall Period
Not Applicable
Time to Complete
30 minutes including set-up time
Application
Mode of Assessment
Administered by trained evaluator
 
Age Group
Children (2 to 11 Years)
Adolescents (12 to 15 Years)
Adults (16 Years and Over)
 
Age Related Limitations
The individual is old enough to understand (using best clinical judgment) what he/she is being asked to do and can complete the test.
Languages
  Original Definitive Validated Translation Informal Translation
English UK     X
English US     X
Conditions of Use and Contact Information
Conditions of Use
Free Access
 
Copyright Owner
Unknown
Contact Name
Unknown
Organisation Name
Unknown
Postal Address
Unknown
URL (Web Address)
Unknown
Email Address
florencej @ neuro.wustl.edu
Phone
314-362-6983
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Functional Tasks
Activity/Task - Lower Limb
Walk
Level of Difficulty/Resistence
Self Determined
Time Allowed
Predetermined
6 Minutes
Rest: Permitted/Required
Rest is Permitted During Test
NB: If participant needs to sit and rest, test is deemed complete.
Motion at Commencement and Time at Rest
Motionless
 
Monitoring and Safety Measures
Pulse/Heart Rate
Blood Pressure
Visual Observation
Respiratory Rate
Monitoring and Safety: Additional Information
Evaluation prior to the test to determine that it is safe (using best clinical judgment) for subject to perform the test.
Assistance Permitted
Use of assistive devices and orthotics, such as ankle braces (AFOs, SMOs) walkers, crutches, or canes are permitted. Record the use and type of assistive device or orthotic on the SD/CRF.
Restrictions
Only subjects who can walk safely without hand held assistance should be permitted to perform the 6MWT.
Instructions
Refer to the ICC 6MWT Protocol for Spinal Muscular Atrophy for detailed instructions on the conduct of the test and a list of equipment needed to perform the test.
Scoring Basis
Distance Travelled
 
Measurements
Pulse/Heart Rate (HR)
Respiratory Rate (RR)
Blood Pressure (BP)
Results
Unknown
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Functional Tasks - Stand/Walk/Run
Distance
Actual Distance Travelled
 
Surface Conditions
Hard Floor (e.g cement)
Smooth Texture
Even
 
 
Gradient
Flat
 
Direction
180 Degree Turn
Number of Turns Permitted
The test is performed on a fixed course, with a length of 25 meters marked on the testing room or hallway floor. Participants are instructed to walk back and forth around the cones at each end of the course. The number of turns is therefore determined by the distance travelled by each participant.
Feet
Shod
comfortable walking shoes (e.g. sneakers)
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Spinal Muscular Atrophy (SMA) Information
Core OM
Unknown
OM Pool
Unknown
Available Validations
Available Validations
Reliability (Internal Consistency)
Validation Limitations
 
Unknown
Validation References
If an OM has been annotated as having an specific type of validation available, you should find a link to the relevant publication in the References section at the bottom of this form. Validtion References are clearly labelled for ease of identification. In the event you can't find a link to a reference, please let us know.
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Reference 1
Type of Reference
Miscellaneous
Reference Details
E. Mazzone, G. Vasco, M.P. Sormani, Y. Torrente, A. Berardinelli, S. Messina, A. D'Amico, L. Doglio, L. Politano, F. Cavallaro, S. Frosini, L. Bello, S. Bonfiglio, E. Zucchini, R. De Sanctis, M. Scutifero, F. Bianco, F. Rossi, M.C. Motta, A. Sacco, M.A. Donati, T. Mongini, A. Pini, R. Battini, E. Pegoraro, M. Pane, S. Gasperini, S. Previtali, S. Napolitano, D. Martinelli, C. Bruno, G. Vita, G. Comi, E. Bertini, E. Mercuri; (2011) Functional changes in Duchenne muscular dystrophy A 12-month longitudinal cohort study; Neurology; Vol. 77; Iss 1;
Web Address (URL)
http://www.neurology.org/content/early/2011/07/06/WNL.0b013e318225ab2e
Reference File ID
Not Applicable
Other Information
Unknown
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Reference 2
Type of Reference
Validation Reference
Reference Details
Kierkegaard, M.; Tollbäck, A.; (2007) Reliability and feasibility of the six minute walk test in subjects with myotonic dystrophy; Neuromuscular Disorders; December Vol. 17; Iss. 11; pp 943-949
Web Address (URL)
http://www.nmd-journal.com/article/S0960-8966(07)00687-6/abstract
Reference File ID
Not Applicable
Other Information
The objective was to describe test–retest reliability and feasibility of the six minute walk test in adult subjects with myotonic dystrophy type 1.
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Reference 3
Type of Reference
Miscellaneous
Reference Details
Ledoux, I.; Decostre, V.; Canal, A.; Hogrel, J.Y.; (2009) M.P.3.09 Relation between total power estimated from 3D accelerometric data and distance covered during the six-minute walk test; Neuromuscular Disorders; September Vol. 19; Iss. 8; pp 603-604
Web Address (URL)
http://www.nmd-journal.com/article/S0960-8966(09)00347-2/abstract
Reference File ID
Not Applicable
Other Information
The aim of this study was to study the relation between total power estimated from 3D-accelerometric data and distance covered during six-minute walk test.
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Reference 4
Type of Reference
Miscellaneous
Reference Details
Escolar, D.M.; Wokke, J.H.J.; Pestronk, A.; Carter, G.T.; Jaffe, K.M.; Laforęt, P.; (2006) G.P.1 01 Clinical presentation and disease progression in late-onset Pompe disease; Neuromuscular Disorders; October; Vol. 16; Iss. 9; p 654
Web Address (URL)
http://www.nmd-journal.com/article/S0960-8966(06)00205-7/abstract
Reference File ID
Not Applicable
Other Information
The objective of this study was to characterize the clinical presentation of individuals with late-onset Pompe disease for the purpose of identifying outcome measures for future clinical trials.
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Reference 5
Type of Reference
Unknown
Reference Details
P. Laforet, P.R. Clemens, D. Corzo, D. Escolar, J. Florence, A. van der Ploeg, S. Lake, J. Mayhew, A. Pestronk, B. Rosenbloom, A. Skrinar, M. Wasserstein; (2008) T.O.4 Safety and efficacy results from a randomized, double-blind, placebo-controlled study of alglucosidase alfa for the treatment of Pompe disease in juveniles and adults; Neuromuscular Disorders; October; Vol. 18; Iss. 9; pp 832-833
Web Address (URL)
http://www.nmd-journal.com/article/S0960-8966(08)00545-2/abstract
Reference File ID
Not Applicable
Other Information
Unknown
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Reference 6
Type of Reference
Unknown
Reference Details
J.M. Florence, A. van der Ploeg, P.R. Clemens, D.M. Escolar, P. Laforet, B. Rosenbloom, M. Wasserstein, A. Skrinar, A. Pestronk, J.E. Mayhew; (2008) T.P.1.01 Use of the 6min walk test as an endpoint in clinical trials for neuromuscular diseases; Neuromuscular Disorders; October; Vol. 18; Iss.; 9; pp 738-739
Web Address (URL)
http://www.nmd-journal.com/article/S0960-8966(08)00215-0/abstract
Reference File ID
Not Applicable
Other Information
Unknown
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Reference 7
Reference Type
Unknown
Reference Details
C.M. McDonald, E.K. Henricson, J.J. Han, A.R. Nicorici, R.T. Abresch, L.A. Atkinson, A.L. Reha, G.L. Elfring, L.L. Miller (2008) T.P.1.02 The 6min walk test (6MWT) as a clinical trial outcome measure in Duchenne/Becker Muscular Dystrophy (DMD/BMD); Neuromuscular Disorders; October Vol. 18; Iss. 9; p 739
Web Address (URL)
Unknown
Reference File ID
Not Applicable
Other Information
Unknown
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Reference 8
Reference Type
Unknown
Reference Details
C. McDonald, E. Henricson, R.T. Abresch, A. Nicorici, L. Atkinson, A. Reha, G.L. Elfring, L.L. Miller; (2009) M.P.3.03 6-minute walk test in Duchenne muscular dystrophy: Longitudinal observations; Neuromuscular Disorders; September; Vol. 19; Iss.; 8; pp 601-602
Web Address (URL)
http://www.nmd-journal.com/article/S0960-8966(09)00341-1/abstract
Reference File ID
Not Applicable
Other Information
Unknown
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Reference 9
Reference Type
Miscellaneous
Reference Details
J. Montes, M.P. McDermott, W.B. Martens, S. Dunaway, A.M. Glanzman, S. Riley, J. Quigley, M.J. Montgomery, D. Sproule, R. Tawil, W. K. Chung, B. T. Darras, D.C. De Vivo, P. Kaufmann, R.S. Finkel; (2010) Six-Minute Walk Test demonstrates motor fatigue in spinal muscular atrophy; Neurology; Vol. 74; pp. 833-838
Web Address (URL)
http://www.neurology.org/cgi/content/abstract/74/10/833
Reference File ID
Not Applicable
Other Information
Unknown