MyoTone Test
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General Information
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| Objectives |
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The MyoTone test purpose is to assess myotonia since there is a real lack of objective methods to quantify myotonia.
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| Category of Outcome Measure |
Pathology
Impairment
Functional
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| Chronology of Development |
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2004: due to a lack of any quantified method for myotonia measurement, clinicians were demanding a specific tool for therapeutic trials. 2005: first tests with various standardized protocols on controls and DM1 patients with an analog grip handle. A protocol and mathematical model to describe force relaxation were chosen and validated on first subjects.
Since 2006: this test has been used on several DM1 and DM2 patients. A short report has been submitted for publication in 2008. The test has been chosen as an outcome measure in at least two clinical trials under development.
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| Mode of Assessment |
Administered by trained evaluator
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| Age Group |
Children (2 to 11 Years)
Adolescents (12 to 15 Years)
Adults (16 Years and Over)
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| Conditions of Use and Contact Information |
| Conditions of Use |
Require Author's Written Permission
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| Organisation Name |
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Institut de Myologie (AIM)
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| Postal Address |
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GH Pitié-Salpêtrière, Bâtiment Babinski, 47/83 Bd de l'Hôpital, Paris Cedex 13, 75651, France
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| Phone |
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+33 (0)1 42 16 58 58 or 58 80
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Device
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| Description |
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MyoTone test can be performed with any analog grip handle. At the Institut of Myologie, we've been using either a MIE grip handle or the MyoGrip prototype. This test is consisting in the measurement of reaction time, maximal voluntary grip strength and relaxation times following a standardized contraction. For modeling we have been using a software commercially available (GraphPad, Prism).
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| Purpose/Use |
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The test is used for myotonia quantification.
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| Organisation Name |
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Institut de Myologie (AIM)
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| Address |
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GH Pitié-Salpêtrière, Bâtiment Babinski, 47/83 Bd de l'Hôpital, Paris Cedex 13, 75651, France
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| Instruction Manual Availability |
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Reference 1
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| Reference Details |
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Hogrel JY (2009) Quantitative myotonia assessment using force relaxation curve modeling, Physiol Meas 30:719–727.
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Reference 2
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| Reference Details |
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Hogrel JY.; (2008) Using force curve modelling for the evaluation of myotonia, Proc Myology 2008
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